Northwestern University Feinberg School of Medicine
Mesulam Institute for Cognitive Neurology
& Alzheimer's Disease

Publications

  1. Lagarde J, Maiti P, Schonhaut DR, Blazhenets G, Zhang J, Eloyan A, Thangarajah M, Taurone A, Allen IE, Soleimani-Meigooni DN  et al.  Amyloid PET in Sporadic Early- Versus Late-Onset Alzheimer's Disease: Comparison of the LEADS and ADNI Cohorts.  Ann Neurol  2025 Aug;98(2):236-248. doi:10.1002/ana.27233
  2. Li E, Chakraborty A, Kohtz SJ, Cajigas I, Hinojosa-Gonzalez L, Shiau F, Bertossi R, Vassar RJ, Kessler JA, Ay F  et al.  Single-cell transcriptomics of ventral forebrain progenitors identifies Evf2 enhancer lncRNA-enhancer gene guidance through direct RNA binding and RNP recruitment domains.  Nat Commun  2025 Jul 26;16(1):6902. pii:6902
  3. Kawles A, Zouridakis A, Nelson C, Keszycki R, Minogue G, Macomber A, Jamshidi P, Castellani RJ, Geula C, Gefen T  et al.  Dendritic location of dystrophic neurites in FTLD-TDP type C with annexinopathy.  Brain Pathol  2025 Jul 23;:e70032. doi:10.1111/bpa.70032
  4. Smith HL, Duckett DJ, Mejia-Bautista M, Alshawa A, Jamshidi P, Castellani RJ, Lukas RV, Chandler JP, Jennings LJ, Santana-Santos L  et al.  IDH-wildtype astrocytoma with FH mutation, epigenetic similarity to IDH-mutant astrocytoma, and hypermethylation of CDKN2A arising in the brainstem.  J Neuropathol Exp Neurol  2025 Jul 22;. pii:nlaf086
  5. Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL  et al.  Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease.  Genome Biol  2025 Jul 17;26(1):210. pii:210
  6. Fares J, Jamshidi P, Congivaram HT, Oyon D, Bautista MM, Kern RC, Brat DJ, Youngblood MW, Chandler JP  Primary papillary epithelial tumor of the sella harboring an EZH2 Y646F mutation.  Acta Neuropathol  2025 Jul 15;150(1):4. pii:4
  7. Castellani RJ, Kostelecky N, Ahrendsen JT, Nassan M, Jamshidi P, Iverson GL  Neurological Disorders and Clinical Progression in Boxers from the 20th Century: A Narrative Review.  Brain Sci  2025 Jul 08;15(7). pii:729
  8. Hanson BA, Dang X, Jamshidi P, Steffens A, Copenhaver K, Orban ZS, Bustos B, Lubbe SJ, Castellani RJ, Koralnik IJ  Human pegivirus alters brain and blood immune and transcriptomic profiles of patients with Parkinson's disease.  JCI Insight  2025 Jul 08;10(13). pii:e189988
  9. Multz RA, Jamshidi P, Ahrendsen JT  Multiple sclerosis: a practical review for pathologists.  J Pathol Transl Med  2025 Jul;59(4):203-213. doi:10.4132/jptm.2025.05.20
  10. Chandra S, Popovic J, Singhal NK, Watkins EA, Dodiya HB, Weigle IQ, Salvo MA, Ramakrishnan A, Chen Z, Watson T  et al.  The gut microbiome controls reactive astrocytosis during Aβ amyloidosis via propionate-mediated regulation of IL-17.  J Clin Invest  2025 Jul 01;135(13). pii:e180826
  11. Vormittag-Nocito E, Duckett D, Castellani RJ, Ahrendsen JT, Lu X, Jennings LJ, Lukas RV, Magill ST, Santana-Santos L, Brat DJ  et al.  Meningiomas With Chromosomal Polysomies Reveal Nonrandom Gain of Chromosomes, Distinct Methylation Signature, and Lower Risk of Recurrence.  Mod Pathol  2025 Jul;38(7):100775. doi:10.1016/j.modpat.2025.100775
  12. Peng W, Bonakdarpour B  The Case of a 67-Year-Old Man With Memory Difficulties and Altered Sleep.  Ann Clin Transl Neurol  2025 Jul;12(7):1511-1513. doi:10.1002/acn3.70027
  13. Fernandopulle MS, Cotty-Fattal Z, Smith H, Mejia Bautista M, Ahrendsen JT, Jennings LJ, Santana-Santos L, Sukhanova M, Conway K, Primdahl D  et al.  Dual TERT promoter mutations in an oligodendroglioma, IDH-mutant, 1p/19q co-deleted.  J Neuropathol Exp Neurol  2025 Jul 01;84(7):658-660. doi:10.1093/jnen/nlae138
  14. Iverson GL, Jamshidi P, Deep-Soboslay A, Hyde TM, Kleinman JE, Hazrati LN, Castellani RJ  Postmortem tau in the CA2 region of the hippocampus in older adult men who participated in youth amateur American-style football.  J Alzheimers Dis  2025 Jun 26;:13872877251351524. doi:10.1177/13872877251351524
  15. Herrold AA, Aaronson AL, Bhaumik D, Durazzo T, Livengood SL, Ramic A, Riordan P, Jordan N, Parrish T, Mallinson T  et al.  A Customized Neural Transcranial Magnetic Stimulation Target for Functional Disability Among Veterans With Co-Occurring Alcohol Use Disorder and Mild Traumatic Brain Injury: Protocol for a Pilot Randomized Controlled Trial.  JMIR Res Protoc  2025 Jun 23;14:e64909. pii:e64909
  16. Castellani RJ, Najem H, Heimberger AB, Jamshidi P  Myeloid-mediated cerebral amyloid vasculitis and the potential role of the immune response in brain atrophy.  J Clin Invest  2025 Jun 19;. pii:e195137
  17. Mather MA, Ece B, Karpouzian-Rogers T, Ho EH, Bucko P, Dworak EM, Novack MA, Pila S, Hosseinian Z, Hanmer J  et al.  Measures of healthcare decision-making ability in cognitive aging: a scoping review from the Advancing Reliable Measurement in Cognitive Aging and Decision-Making Ability (ARMCADA) research initiative.  Front Public Health  2025;13:1582764. pii:1582764
  18. Xu T, Su T, Soye BJD, Kandi S, Huang CF, Wilkins JT, Castellani RJ, Kafader JO, Patrie SM, Vassar R  et al.  The Proteoform Landscape of Tau from the Human Brain.  J Proteome Res  2025 Jun 06;24(6):2916-2925. doi:10.1021/acs.jproteome.5c00139
  19. Karunakaran DKP, Ley M, Guo J, Khatri A, Sadleir K, Popovic J, Upadhyay AK, Savas J, Procissi D, Atwal J  et al.  The UNC5C T835M mutation associated with Alzheimer's disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged mice.  Mol Neurodegener  2025 Jun 04;20(1):65. pii:65
  20. Wirtshafter HS, Solla SA, Disterhoft JF  A universal hippocampal memory code across animals and environments.  bioRxiv  2025 Jun 03;. pii:2024.10.24.620127
  21. Bonakdarpour B, Schafer R, Takarabe C, Barbieri E, Miller J, Miller SS  Virtual group singing programs for well-being in healthy older adults and persons with neurocognitive disorders during early COVID-19 pandemic: A perspective from Chicago.  J Alzheimers Dis  2025 Jun;105(3):904-922. doi:10.1177/13872877251333155
  22. Le Borgne J, Gomez L, Heikkinen S, Amin N, Ahmad S, Choi SH, Bis J, Grenier-Boley B, Rodriguez OG, Kleineidam L  et al.  X-chromosome-wide association study for Alzheimer's disease.  Mol Psychiatry  2025 Jun;30(6):2335-2346. doi:10.1038/s41380-024-02838-5
  23. Koh Y, Vázquez-Rosa E, Gao F, Li H, Chakraborty S, Tripathi SJ, Barker S, Bud Z, Bangalore A, Kandjoze UP  et al.  Inhibiting 15-PGDH blocks blood-brain barrier deterioration and protects mice from Alzheimer's disease and traumatic brain injury.  Proc Natl Acad Sci U S A  2025 May 27;122(21):e2417224122. pii:e2417224122
  24. Sadleir KR, Gomez KP, Edwards AE, Patel AJ, Ley ML, Khatri AW, Guo J, Mahesh S, Watkins EA, Popovic J  et al.  Annexin A6 membrane repair protein protects against amyloid-induced dystrophic neurites and tau phosphorylation in Alzheimer's disease model mice.  Acta Neuropathol  2025 May 24;149(1):51. pii:51
  25. Bucaloiu A, Jamshidi P, Dixit K, Sukhanova M, Tariq H  Diagnostic utility of plasma circulating tumor DNA (ctDNA) in primary large B-cell lymphoma of the central nervous system (PCNS-LBCL): A paradigm shift?  Leuk Lymphoma  2025 May 23;:1-4. doi:10.1080/10428194.2025.2508298
  26. Ho EH, Karpouzian-Rogers T, Ayturk E, Bedjeti K, Weintraub S, Gershon R  NIH Toolbox Cognition Performance in Older Adults with Normal Cognition, Mild Cognitive Impairment, and Mild Dementia of the Alzheimer's Type: Results from the ARMADA Study.  Arch Clin Neuropsychol  2025 May 14;. pii:acaf035
  27. Burt AL, Daly MP, Sherman JC, Schmahmann JD,   The Cerebellar Neuropsychiatric Rating Scale in the Spinocerebellar Ataxias.  Cerebellum  2025 May 05;24(4):94. doi:10.1007/s12311-025-01840-z
  28. van Olst L, Simonton B, Edwards AJ, Forsyth AV, Boles J, Jamshidi P, Watson T, Shepard N, Krainc T, Argue BM  et al.  Author Correction: Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer's disease.  Nat Med  2025 May;31(5):1712. doi:10.1038/s41591-025-03664-0
  29. van Olst L, Simonton B, Edwards AJ, Forsyth AV, Boles J, Jamshidi P, Watson T, Shepard N, Krainc T, Argue BM  et al.  Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer's disease.  Nat Med  2025 May;31(5):1604-1616. doi:10.1038/s41591-025-03574-1
  30. Kragel JE, Lurie SM, Issa NP, Haider HA, Wu S, Tao JX, Warnke PC, Schuele S, Rosenow JM, Zelano C  et al.  Closed-loop control of theta oscillations enhances human hippocampal network connectivity.  Nat Commun  2025 Apr 30;16(1):4061. pii:4061
  31. Pottier C, Küçükali F, Baker M, Batzler A, Jenkins GD, van Blitterswijk M, Vicente CT, De Coster W, Wynants S, Van de Walle P  et al.  Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing.  Nat Commun  2025 Apr 25;16(1):3914. pii:3914
  32. Kim M, Rogers L, Batio S, Benavente JY, Bonham M, Zheng P, Lovett RM, Bailey SC, Kwasny MJ, Ladner DP  et al.  Trajectories of sleep disturbance and self-management of chronic conditions during COVID-19 among middle-aged and older adults.  Sci Rep  2025 Apr 10;15(1):12324. pii:12324
  33. Liu X, de Boer SCM, Cortez K, Poos JM, Illán-Gala I, Heuer H, Forsberg LK, Casaletto K, Memel M, Appleby BS  et al.  Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia.  Alzheimers Dement  2025 Apr;21(4):e14608. pii:e14608
  34. Gettel C, Galske J, Araujo K, Dresden S, Dussetschleger J, Iannone L, Lai J, Martin P, Mignosa B, Muschong K  et al.  Detection and differentiation of undiagnosed dementia in the emergency department: A pilot referral pathway.  Alzheimers Dement  2025 Apr;21(4):e70189. pii:e70189
  35. Hammers DB, Musema J, Eloyan A, Thangarajah M, Taurone A, La Joie R, Touroutoglou A, Vemuri P, Kramer J, Aisen P  et al.  Characterizing and validating 12-month reliable cognitive change in Early-Onset Alzheimer's Disease for use in clinical trials.  J Prev Alzheimers Dis  2025 Apr;12(4):100075. pii:100075
  36. O'Conor R, Pack A, Russell AM, Oladejo D, Rogalski E, Morhardt D, Fortinsky RH, Lindquist LA, Persell SD, Wolf MS  Triadic Primary Care Encounters Managing Medications among Individuals with Mild Cognitive Impairment and Dementia: Patient, Caregiver and Clinician Perspectives.  Gerontologist  2025 Mar 28;. pii:gnaf122
  37. Karpouzian-Rogers T, Dworak EM, Bucko P, Ho EH, Ece B, Mather MA, Novack MA, Pila S, Hosseinian Z, Hall L  et al.  Measures of decision-making ability and functional outcomes in older adults: results from a scoping review in the ARMCADA study.  Front Psychol  2025;16:1540493. pii:1540493
  38. Ho EH, Ece B, Bucko P, Karpouzian-Rogers T, Pila S, Hosseinian Z, Hussein Y, Han SD, Lichtenberg PA, Lim AC  et al.  A scoping review of financial decision-making measures in midlife and beyond: results from the advancing reliable measurement in cognitive aging and decision-making ability (ARMCADA) study.  Front Psychol  2025;16:1540508. pii:1540508
  39. Sheth U, Öijerstedt L, Heckman MG, White LJ, Heuer HW, Lario Lago A, Forsberg LK, Faber KM, Foroud TM, Rademakers R  et al.  Comprehensive cross-sectional and longitudinal comparisons of plasma glial fibrillary acidic protein and neurofilament light across FTD spectrum disorders.  Mol Neurodegener  2025 Mar 12;20(1):30. pii:30
  40. Daly MP, Sherman JC, Schmahmann JD  The Cerebellar Neuropsychiatric Rating Scale.  Cerebellum  2025 Mar 04;24(2):56. doi:10.1007/s12311-025-01799-x
  41. Rogalski E, Bona M, Esparza M, Fegter O, Schafer R, Mooney A, Fried-Oken M, Rademaker A, Roberts A  Efficacy of Communication Bridge-2 for primary progressive aphasia: A randomized controlled trial of communication intervention.  Alzheimers Dement  2025 Mar;21(3):e70088. pii:e70088
  42. Tiek D, Song X, Yu X, Wu R, Iglesia R, Catezone A, McCortney K, Walshon J, Horbinski C, Jamshidi P  et al.  Oxidative stress induced protein aggregation via GGCT produced pyroglutamic acid in drug resistant glioblastoma.  iScience  2025 Feb 21;28(2):111769. pii:111769
  43. Putcha D, Katsumi Y, Touroutoglou A, Eloyan A, Taurone A, Thangarajah M, Aisen P, Dage JL, Foroud T, Jack CR  et al.  Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer's disease: a neuropsychological data-driven approach.  Alzheimers Res Ther  2025 Feb 06;17(1):38. pii:38
  44. Katsumi Y, Touroutoglou A, Brickhouse M, Eloyan A, Eckbo R, Zaitsev A, La Joie R, Lagarde J, Schonhaut D, Thangarajah M  et al.  Dissociable spatial topography of cortical atrophy in early-onset and late-onset Alzheimer's disease: A head-to-head comparison of the LEADS and ADNI cohorts.  Alzheimers Dement  2025 Feb;21(2):e14489. pii:e14489
  45. Vargas-Gonzalez JC, Dimal N, Cortez K, Heuer H, Forsberg LK, Appleby BS, Barmada S, Bozoki A, Clark D, Cobigo Y  et al.  Psychotropic medication usage in sporadic versus genetic behavioral-variant frontotemporal dementia.  Alzheimers Dement  2025 Feb;21(2):e14448. pii:e14448
  46. Hammers DB, Eloyan A, Taurone A, Thangarajah M, Gao S, Beckett L, Polsinelli AJ, Kirby K, Dage JL, Nudelman K  et al.  Longitudinal cognitive performance of participants with sporadic early onset Alzheimer's disease from LEADS.  Alzheimers Dement  2025 Feb;21(2):e14439. pii:e14439
  47. Fortington LV, Cassidy JD, Castellani RJ, Gardner AJ, McIntosh AS, Austen M, Kerr ZY, Quarrie KL  Epidemiological Principles in Claims of Causality: An Enquiry into Repetitive Head Impacts (RHI) and Chronic Traumatic Encephalopathy (CTE).  Sports Med  2025 Feb;55(2):255-274. doi:10.1007/s40279-024-02102-4
  48. Finley JA, Slotkin J, Nowinski CJ, Bedjeti K, Volpe N, Weintraub S, Gershon R  Near vision assessment for adults using the NIH Toolbox.  Front Neurol  2025;16:1533382. pii:1533382
  49. Jutten RJ, Ho EH, Karpouzian-Rogers T, van Hulle C, Carlsson C, Dodge HH, Nowinski CJ, Gershon R, Weintraub S, Rentz DM  Computerized cognitive testing to capture cognitive decline in Alzheimer's disease: Longitudinal findings from the ARMADA study.  Alzheimers Dement (Amst)  2025;17(1):e70046. pii:e70046
  50. Duckett D, Vormittag-Nocito ER, Jamshidi P, Sukhanova M, Parker S, Brat DJ, Jennings LJ, Santana-Santos L  Accurate identification of primary site in tumors of unknown origin (TUO) using DNA methylation.  NPJ Precis Oncol  2025 Jan 10;9(1):8. pii:8

Follow Mesulam Institute on