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Northwestern University Feinberg School of Medicine
Mesulam Center for Cognitive Neurology and Alzheimer’s Disease

Publications

  1. Xu T, Su T, Soye BJD, Kandi S, Huang CF, Wilkins JT, Castellani RJ, Kafader JO, Patrie SM, Vassar R  et al.  The Proteoform Landscape of Tau from the Human Brain.  J Proteome Res  2025 Jun 06;24(6):2916-2925. doi:10.1021/acs.jproteome.5c00139
  2. Karunakaran DKP, Ley M, Guo J, Khatri A, Sadleir K, Popovic J, Upadhyay AK, Savas J, Procissi D, Atwal J  et al.  The UNC5C T835M mutation associated with Alzheimer's disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged mice.  Mol Neurodegener  2025 Jun 04;20(1):65. pii:65
  3. Bonakdarpour B, Schafer R, Takarabe C, Barbieri E, Miller J, Miller SS  Virtual group singing programs for well-being in healthy older adults and persons with neurocognitive disorders during early COVID-19 pandemic: A perspective from Chicago.  J Alzheimers Dis  2025 Jun;105(3):904-922. doi:10.1177/13872877251333155
  4. Le Borgne J, Gomez L, Heikkinen S, Amin N, Ahmad S, Choi SH, Bis J, Grenier-Boley B, Rodriguez OG, Kleineidam L  et al.  X-chromosome-wide association study for Alzheimer's disease.  Mol Psychiatry  2025 Jun;30(6):2335-2346. doi:10.1038/s41380-024-02838-5
  5. Koh Y, Vázquez-Rosa E, Gao F, Li H, Chakraborty S, Tripathi SJ, Barker S, Bud Z, Bangalore A, Kandjoze UP  et al.  Inhibiting 15-PGDH blocks blood-brain barrier deterioration and protects mice from Alzheimer's disease and traumatic brain injury.  Proc Natl Acad Sci U S A  2025 May 27;122(21):e2417224122. pii:e2417224122
  6. Sadleir KR, Gomez KP, Edwards AE, Patel AJ, Ley ML, Khatri AW, Guo J, Mahesh S, Watkins EA, Popovic J  et al.  Annexin A6 membrane repair protein protects against amyloid-induced dystrophic neurites and tau phosphorylation in Alzheimer's disease model mice.  Acta Neuropathol  2025 May 24;149(1):51. pii:51
  7. Bucaloiu A, Jamshidi P, Dixit K, Sukhanova M, Tariq H  Diagnostic utility of plasma circulating tumor DNA (ctDNA) in primary large B-cell lymphoma of the central nervous system (PCNS-LBCL): A paradigm shift?  Leuk Lymphoma  2025 May 23;:1-4. doi:10.1080/10428194.2025.2508298
  8. Ho EH, Karpouzian-Rogers T, Ayturk E, Bedjeti K, Weintraub S, Gershon R  NIH Toolbox Cognition Performance in Older Adults with Normal Cognition, Mild Cognitive Impairment, and Mild Dementia of the Alzheimer's Type: Results from the ARMADA Study.  Arch Clin Neuropsychol  2025 May 14;. pii:acaf035
  9. Chandra S, Popovic J, Singhal NK, Watkins EA, Dodiya HB, Weigle IQ, Salvo MA, Ramakrishnan A, Chen Z, Watson JT  et al.  The gut microbiome controls reactive astrocytosis during Aβ amyloidosis via propionate-mediated regulation of IL-17.  J Clin Invest  2025 May 13;. pii:e180826
  10. Burt AL, Daly MP, Sherman JC, Schmahmann JD,   The Cerebellar Neuropsychiatric Rating Scale in the Spinocerebellar Ataxias.  Cerebellum  2025 May 05;24(4):94. doi:10.1007/s12311-025-01840-z
  11. van Olst L, Simonton B, Edwards AJ, Forsyth AV, Boles J, Jamshidi P, Watson T, Shepard N, Krainc T, Argue BM  et al.  Author Correction: Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer's disease.  Nat Med  2025 May;31(5):1712. doi:10.1038/s41591-025-03664-0
  12. van Olst L, Simonton B, Edwards AJ, Forsyth AV, Boles J, Jamshidi P, Watson T, Shepard N, Krainc T, Argue BM  et al.  Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer's disease.  Nat Med  2025 May;31(5):1604-1616. doi:10.1038/s41591-025-03574-1
  13. Kragel JE, Lurie SM, Issa NP, Haider HA, Wu S, Tao JX, Warnke PC, Schuele S, Rosenow JM, Zelano C  et al.  Closed-loop control of theta oscillations enhances human hippocampal network connectivity.  Nat Commun  2025 Apr 30;16(1):4061. pii:4061
  14. Pottier C, Küçükali F, Baker M, Batzler A, Jenkins GD, van Blitterswijk M, Vicente CT, De Coster W, Wynants S, Van de Walle P  et al.  Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing.  Nat Commun  2025 Apr 25;16(1):3914. pii:3914
  15. Vormittag-Nocito E, Duckett D, Castellani RJ, Ahrendsen JT, Lu X, Jennings LJ, Lukas RV, Magill ST, Santana-Santos L, Brat DJ  et al.  Meningiomas With Chromosomal Polysomies Reveal Nonrandom Gain of Chromosomes, Distinct Methylation Signature, and Lower Risk of Recurrence.  Mod Pathol  2025 Apr 14;38(7):100775. doi:10.1016/j.modpat.2025.100775
  16. Kim M, Rogers L, Batio S, Benavente JY, Bonham M, Zheng P, Lovett RM, Bailey SC, Kwasny MJ, Ladner DP  et al.  Trajectories of sleep disturbance and self-management of chronic conditions during COVID-19 among middle-aged and older adults.  Sci Rep  2025 Apr 10;15(1):12324. pii:12324
  17. Liu X, de Boer SCM, Cortez K, Poos JM, Illán-Gala I, Heuer H, Forsberg LK, Casaletto K, Memel M, Appleby BS  et al.  Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia.  Alzheimers Dement  2025 Apr;21(4):e14608. pii:e14608
  18. Gettel C, Galske J, Araujo K, Dresden S, Dussetschleger J, Iannone L, Lai J, Martin P, Mignosa B, Muschong K  et al.  Detection and differentiation of undiagnosed dementia in the emergency department: A pilot referral pathway.  Alzheimers Dement  2025 Apr;21(4):e70189. pii:e70189
  19. Hammers DB, Musema J, Eloyan A, Thangarajah M, Taurone A, La Joie R, Touroutoglou A, Vemuri P, Kramer J, Aisen P  et al.  Characterizing and validating 12-month reliable cognitive change in Early-Onset Alzheimer's Disease for use in clinical trials.  J Prev Alzheimers Dis  2025 Apr;12(4):100075. doi:10.1016/j.tjpad.2025.100075
  20. O'Conor R, Pack A, Russell AM, Oladejo D, Rogalski E, Morhardt D, Fortinsky RH, Lindquist LA, Persell SD, Wolf MS  Triadic Primary Care Encounters Managing Medications among Individuals with Mild Cognitive Impairment and Dementia: Patient, Caregiver and Clinician Perspectives.  Gerontologist  2025 Mar 28;. pii:gnaf122
  21. Peng W, Bonakdarpour B  The Case of a 67-Year-Old Man With Memory Difficulties and Altered Sleep.  Ann Clin Transl Neurol  2025 Mar 27;. doi:10.1002/acn3.70027
  22. Karpouzian-Rogers T, Dworak EM, Bucko P, Ho EH, Ece B, Mather MA, Novack MA, Pila S, Hosseinian Z, Hall L  et al.  Measures of decision-making ability and functional outcomes in older adults: results from a scoping review in the ARMCADA study.  Front Psychol  2025;16:1540493. pii:1540493
  23. Ho EH, Ece B, Bucko P, Karpouzian-Rogers T, Pila S, Hosseinian Z, Hussein Y, Han SD, Lichtenberg PA, Lim AC  et al.  A scoping review of financial decision-making measures in midlife and beyond: results from the advancing reliable measurement in cognitive aging and decision-making ability (ARMCADA) study.  Front Psychol  2025;16:1540508. pii:1540508
  24. Lagarde J, Maiti P, Schonhaut DR, Blazhenets G, Zhang J, Eloyan A, Thangarajah M, Taurone A, Allen IE, Soleimani-Meigooni DN  et al.  Amyloid PET in Sporadic Early- Versus Late-Onset Alzheimer's Disease: Comparison of the LEADS and ADNI Cohorts.  Ann Neurol  2025 Mar 17;. doi:10.1002/ana.27233
  25. Sheth U, Öijerstedt L, Heckman MG, White LJ, Heuer HW, Lario Lago A, Forsberg LK, Faber KM, Foroud TM, Rademakers R  et al.  Comprehensive cross-sectional and longitudinal comparisons of plasma glial fibrillary acidic protein and neurofilament light across FTD spectrum disorders.  Mol Neurodegener  2025 Mar 12;20(1):30. pii:30
  26. Daly MP, Sherman JC, Schmahmann JD  The Cerebellar Neuropsychiatric Rating Scale.  Cerebellum  2025 Mar 04;24(2):56. doi:10.1007/s12311-025-01799-x
  27. Rogalski E, Bona M, Esparza M, Fegter O, Schafer R, Mooney A, Fried-Oken M, Rademaker A, Roberts A  Efficacy of Communication Bridge-2 for primary progressive aphasia: A randomized controlled trial of communication intervention.  Alzheimers Dement  2025 Mar;21(3):e70088. pii:e70088
  28. Tiek D, Song X, Yu X, Wu R, Iglesia R, Catezone A, McCortney K, Walshon J, Horbinski C, Jamshidi P  et al.  Oxidative stress induced protein aggregation via GGCT produced pyroglutamic acid in drug resistant glioblastoma.  iScience  2025 Feb 21;28(2):111769. pii:111769
  29. Putcha D, Katsumi Y, Touroutoglou A, Eloyan A, Taurone A, Thangarajah M, Aisen P, Dage JL, Foroud T, Jack CR  et al.  Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer's disease: a neuropsychological data-driven approach.  Alzheimers Res Ther  2025 Feb 06;17(1):38. pii:38
  30. Katsumi Y, Touroutoglou A, Brickhouse M, Eloyan A, Eckbo R, Zaitsev A, La Joie R, Lagarde J, Schonhaut D, Thangarajah M  et al.  Dissociable spatial topography of cortical atrophy in early-onset and late-onset Alzheimer's disease: A head-to-head comparison of the LEADS and ADNI cohorts.  Alzheimers Dement  2025 Feb;21(2):e14489. pii:e14489
  31. Vargas-Gonzalez JC, Dimal N, Cortez K, Heuer H, Forsberg LK, Appleby BS, Barmada S, Bozoki A, Clark D, Cobigo Y  et al.  Psychotropic medication usage in sporadic versus genetic behavioral-variant frontotemporal dementia.  Alzheimers Dement  2025 Feb;21(2):e14448. pii:e14448
  32. Hammers DB, Eloyan A, Taurone A, Thangarajah M, Gao S, Beckett L, Polsinelli AJ, Kirby K, Dage JL, Nudelman K  et al.  Longitudinal cognitive performance of participants with sporadic early onset Alzheimer's disease from LEADS.  Alzheimers Dement  2025 Feb;21(2):e14439. pii:e14439
  33. Fortington LV, Cassidy JD, Castellani RJ, Gardner AJ, McIntosh AS, Austen M, Kerr ZY, Quarrie KL  Epidemiological Principles in Claims of Causality: An Enquiry into Repetitive Head Impacts (RHI) and Chronic Traumatic Encephalopathy (CTE).  Sports Med  2025 Feb;55(2):255-274. doi:10.1007/s40279-024-02102-4
  34. Finley JA, Slotkin J, Nowinski CJ, Bedjeti K, Volpe N, Weintraub S, Gershon R  Near vision assessment for adults using the NIH Toolbox.  Front Neurol  2025;16:1533382. pii:1533382
  35. Jutten RJ, Ho EH, Karpouzian-Rogers T, van Hulle C, Carlsson C, Dodge HH, Nowinski CJ, Gershon R, Weintraub S, Rentz DM  Computerized cognitive testing to capture cognitive decline in Alzheimer's disease: Longitudinal findings from the ARMADA study.  Alzheimers Dement (Amst)  2025;17(1):e70046. pii:e70046
  36. Fernandopulle MS, Cotty-Fattal Z, Smith H, Mejia Bautista M, Ahrendsen JT, Jennings LJ, Santana-Santos L, Sukhanova M, Conway K, Primdahl D  et al.  Dual TERT promoter mutations in an oligodendroglioma, IDH-mutant, 1p/19q co-deleted.  J Neuropathol Exp Neurol  2025 Jan 11;. pii:nlae138
  37. Duckett D, Vormittag-Nocito ER, Jamshidi P, Sukhanova M, Parker S, Brat DJ, Jennings LJ, Santana-Santos L  Accurate identification of primary site in tumors of unknown origin (TUO) using DNA methylation.  NPJ Precis Oncol  2025 Jan 10;9(1):8. pii:8
  38. Geula C, Ayala I, Gefen T, Mesulam MM  Organization of the basal forebrain cholinergic system in the human brain.  Handb Clin Neurol  2025;211:11-21. doi:10.1016/B978-0-443-19088-9.00009-3
  39. Shaughnessy LW, Weintraub S  The role of neuropsychological assessment in the evaluation of patients with cognitive-behavioral change due to suspected Alzheimer's disease and other causes of cognitive impairment and dementia.  Alzheimers Dement  2025 Jan;21(1):e14363. pii:e14363
  40. Hammers DB, Eloyan A, Thangarajah M, Taurone A, Beckett L, Gao S, Polsinelli AJ, Kirby K, Dage JL, Nudelman K  et al.  Differences in baseline cognitive performance between participants with early-onset and late-onset Alzheimer's disease: Comparison of LEADS and ADNI.  Alzheimers Dement  2025 Jan;21(1):e14218. pii:e14218
  41. Rose S, Gergoire A, Pal S, Reader J, Bhaumik A, Slotkin J, Ho E, Nowinski CJ, Persad CC, Maher AC  et al.  Evaluating the factor structure and construct validity of the NIH toolbox in older adults, with a focus on cognitive normalcy and amnestic mild cognitive impairment: considerations for diversity, including insights from persons over 85 years of age and Black older Americans.  J Int Neuropsychol Soc  2025 Jan;31(1):53-58. doi:10.1017/S1355617724000699
  42. Castellani RJ  Biomarker-only diagnosis of Alzheimer's disease: Not ready for prime time.  J Alzheimers Dis  2025 Jan;103(2):356-357. doi:10.1177/13872877241301805
  43. Rogalski E, Bona M, Esparza M, Mooney A, Fried-Oken M, Rademaker A, Roberts A  Communication Bridge-2 randomized controlled trial: Recruitment and baseline features.  Alzheimers Dement  2025 Jan;21(1):e14168. pii:e14168
  44. Volkmer A, Alves EV, Bar-Zeev H, Barbieri E, Battista P, Beales A, Beber BC, Brotherhood E, Cadorio IR, Carthery-Goulart MT  et al.  An international core outcome set for primary progressive aphasia (COS-PPA): Consensus-based recommendations for communication interventions across research and clinical settings.  Alzheimers Dement  2025 Jan;21(1):e14362. pii:e14362
  45. Smith H, Jean J, Duckett D, Vormittag-Nocito E, Nezami BG, Jennings LJ, Ahrendsen JT, Yang XJ, Primdahl D, Conway K  et al.  Diagnostic utility of multimodal advanced molecular testing to classify metastases of unknown primaries: A case of a patient with no known medical history.  J Neuropathol Exp Neurol  2025 Jan 01;84(1):84-86. doi:10.1093/jnen/nlae086
  46. Ho EH, Ece B, Novack MA, Pila S, Karpouzian-Rogers T, Mather MA, Dworak EM, Hosseinian Z, Bucko P, Kaat AJ  et al.  Protocol for a multi-domain scoping review to identify measures of decision-making ability in an ageing population.  BMJ Open  2024 Dec 22;14(12):e084178. pii:e084178
  47. Shi J, Touchon J, Middleton LT, Rovira MB, Vassar R, Vellas B, Shen Y  Now and future: Strategies for diagnosis, prevention and therapies for Alzheimer's disease.  Sci Bull (Beijing)  2024 Dec 15;69(23):3777-3784. doi:10.1016/j.scib.2024.09.042
  48. Nuytemans K, Franzen S, Broce IJ, Caramelli P, Ellajosyula R, Finger E, Gupta V, Gupta V, Illán-Gala I, Loi SM  et al.  Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research.  Alzheimers Dement  2024 Dec;20(12):9014-9036. doi:10.1002/alz.14312
  49. Haynes G, Muhammad F, Weber KA, Khan AF, Hameed S, Shakir H, Van Hal M, Dickson D, Rohan M, Dhaher Y  et al.  Tract-specific magnetization transfer ratio provides insights into the severity of degenerative cervical myelopathy.  Spinal Cord  2024 Dec;62(12):700-707. doi:10.1038/s41393-024-01036-y
  50. Kostelecky N, Wadhwani N, Golubovich I, Vormittag-Nocito E, Gao J, Jennings L, Caron M, Jamshidi P, Ahrendsen JT, Castellani R  et al.  Transdifferentiation of metastatic melanoma into cerebellar angiosarcoma.  J Neuropathol Exp Neurol  2024 Dec 01;83(12):1081-1083. doi:10.1093/jnen/nlae075

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