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Care, Support & Treatment of PSPS

There are a number of non-pharmacologic ways to support those with Progressive Supranuclear Palsy Syndrome (PSPS). Speech therapy can improve swallowing, language, and communication. Occupational therapy can help provide strategies and techniques to compensate for the cognitive and motor changes associated with PSPS.  Physical therapy can also improve aspects of motor function.  

Treatment (Medications)

Though there is no cure for progessive supranuclear palsy syndrome (PSPS), some medications can be prescribed with the goal of symptom reduction. Levodopa (Sinemet) can be trialed to address the motor symptoms of PSPS. Unfortunately, the response to levodopa is usually very limited.  

Medications can be prescribed to address mood and anxiety symptoms associated with PSPS. These medications can provide relief for affected individuals and their caregivers. Antidepressants can be given to treat depression, anxiety, or irritability. Low doses of antipsychotics may also be considered to help address delusional thinking or aggression.

Support Groups

Mesulam Center Groups


  • This organization, outside of the center, offers support groups, and additional resources for living with PSP. Learn more on the website here.

Support Resources

  • Rock Steady Boxing is an organization that offers a non-contact boxing curriculum for those with Parkinson’s disease and related conditions.  

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