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Care, Support & Treatment of Corticobasal Syndrome

There are a number of non-pharmacologic ways to support those with Corticobasal Syndrome (CBS).  

  • Speech therapy can improve language and communication.  
  • Occupational therapy can help provide strategies and techniques to compensate for the cognitive and motor changes associated with CBS.
  • Physical therapy can also improve aspects of motor function.  

Treatment (Medications)

There are presently no cures for Corticobasal Syndrome, but medications can be prescribed with to treat some of the symptoms. 
  • Though levodopa, a dopamine replacement, (Sinemet) can be given to address the motor symptoms of CBS, symptom response is uncommon and limited. This is in contrast to the motor symptoms of Parkinson’s disease, which typically respond robustly to levodopa administration. 
  • When CBS symptoms are determined to stem from Alzheimer’s disease, a class of medications known as cholinesterase inhibitors might be available. Donepezil (Aricept), Rivastigmine (Exelon) and Galantamine (Razydyne) are examples of cholinesterase inhibitors. These medications increase the level of a neurotransmitter in the brain, acetylcholine, which is important for attention and memory. Common side effects with cholinesterase inhibitors include nausea, diarrhea, and dizziness. 
  • Additionally, medications can be prescribed to address mood and anxiety symptoms associated with CBS. These medications can provide relief for affected individuals and their caregivers. Antidepressants can be given to treat depression, anxiety, or irritability. Low doses of antipsychotics may also be considered to help address delusional thinking (believing things that have no real foundation) or aggression.  

Support Groups

Mesulam Center Groups


  • This organization, outside of the center, offers support groups, and additional resources for living with CBS. Learn more on the website here.


  • Rock Steady Boxing is an organization that offers a non-contact boxing curriculum for those with Parkinson’s disease and related conditions.  

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