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Active Studies

Browse a listing of research studies currently underway and led by Mesulam Center investigators.

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Alzheimer’s Disease Neuroimaging Initiative 3

The overall goal of Alzheimer’s Disease Neuroimaging Initiative 3 (ADNI3) is to determine the relationships among the clinical, cognitive, imaging, genetic and biochemical biomarker characteristics of the entire spectrum of Alzheimer's disease (AD), as the pathology evolves from normal aging through very mild symptoms, to mild cognitive impairment (MCI), to dementia.
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Alzheimer's Disease Core Center

The purpose of the Northwestern Alzheimer’s Disease Center (NADC) research registry is to 1) provide state-of-the-art care to patients with mild cognitive impairment, Alzheimer’s disease and related disorders, and to 2) support clinical and basic research on memory and aging collecting, storing, and disseminating clinical data, brain imaging, and biological samples from research participants to collaborators.
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The overall goal of ALLFTD is to prepare a cohort of individuals with most varieties of frontotemporal lobar degeneration (FTLD) for future studies including clinical trials. FTLD is a neurological disease that causes Frontotemporal Dementia (FTD) syndromes including Primary Progressive Aphasia (PPA) and Behavioral Variant Frontotemporal Dementia (bvFTD), among others.
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Communication Bridge

The Communication Bridge study is an internet-based, speech therapy intervention for individuals with Primary Progressive Aphasia and their Communication Partner. The goal of the study is to help us better understand the effects of speech language therapy on communication abilities in individuals with PPA. All study visits take place over the Internet in the comfort of your home, on a computer we provide for the length of the study.
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Language in Primary Progressive Aphasia

The Language in Primary Progressive Aphasia (PPA) aims to understand the behavioral, anatomical and physiological changes in people with PPA throughout the course of the illness. During the three-day research program, participants will be asked to undergo neuropsychological testing (paper and pencil tests that evaluate cognition), an MRI (a non-invasive brain-imaging procedure), an EEG (another non-invasive procedure that looks at brain waves when you think) and other computer and language testing batteries.
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Longitudinal Early-onset Alzheimer's Disease Study (LEADS)

The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is a non-randomized, natural history, non-treatment study designed to look at disease progression in individuals with early onset Alzheimer's disease (EOAD). Clinical/cognitive, imaging, biomarker, and genetic characteristics will be assessed across two cohorts: (1) individuals with EOAD and (2) cognitively normal (CN) control participants.
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Alzheimer's Prevention Study (TRC-PAD)

This is an observational study that advances Alzheimer’s research by matching healthy people with clinical trials to prevent Alzheimer’s disease. Participants who meet certain criteria and are identified as being at potential increased risk for future memory loss caused by Alzheimer’s disease are eligible. The purpose of this study is to create a trial-ready cohort (TRC) to further dementia research.
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Super Aging Study: Correlates of Active Engagement in Life in the Elderly

The purpose of this study is to identify factors that contribute to the maintenance of functioning in old age (age 80 and above). We will be looking at a variety of factors including cognition, personality traits, psychosocial factors, genetic factors, and brain structure. The second purpose of this study is to look at how performance on these variables changes over time.
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Progranulin Gene Mutation Study

The purpose of this study is to determine if the investigational drug AL001 is effective and safe in treating individuals who have a progranulin gene mutation that causes frontotemporal dementia (FTD). Currently there is no treatment for FTD. 
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The AHEAD Study

An abnormal form of a protein called “amyloid” builds up in the brains of people with Alzheimer’s disease (AD), but not every person with amyloid build up will develop memory problems or AD dementia. The purpose of this study is to determine if an investigational drug reduces the risk of developing AD dementia.


This study seeks to help people diagnosed with any type of mild dementia and their care partner prepare for future medical decisions. This is a collaborative study with Emory University and can be completed remotely.
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