Tissue/Neuropathology Core

Functions of Neuropathology Core of CNADC

• To collect, catalog, and store, postmortem brain tissue and other samples from demented subjects and non-demented control individuals.
• To distribute postmortem brain tissue and other samples to investigators for use in research.
• To provide qualitative and quantitative diagnostic information to physicians, families, and researchers.

Tissue Bank

The CNADC Tissue Bank has many types of specimens available for investigators. In most cases, available tissue includes:

• Brain Tissue
  • paraformaldehyde-fixed wet tissue
  • paraffin blocks of paraformaldehyde-fixed brain
  • frozen unfixed brain samples
  • unstained sections from selected regions
• Plasma from blood samples obtained from living subjects and controls
• DNA extracted from leukocytes of blood samples from living individuals
• Postmortem CSF is available in some cases.

Pathologic diagnoses of postmortem cases available in brain bank:

• No pathologic diagnosis (non-demented control)
• Alzheimer disease
• Dementia with Lewy bodies
• Frontotemporal lobar degeneration (FTLD)
  • FTLD with ubiquitin inclusions (FTLD with motor neuron disease-type inclusions, TDP-43 proteinopathy)
  • Pick disease
  • Corticobasal degeneration
  • Tauopathy, sporadic unclassifiable
  • Tauopathy, familial (FTDP-17)
  • Progressive supranuclear palsy
  • Tangle-predominant senile dementia
• Amyotrophic lateral sclerosis / motor neuron disease
• Vascular dementia

Related Information

Brain Endowment

Tissue Request Form

NADC Data Available