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Northwestern Alzheimer's Disease Center (NADC)
The Northwestern Alzheimer's Disease Center (NADC) maintains a registry of
research participants for whom we have clinical data and tissue samples. The
research participants include individuals over age 50 with no cognitive
impairment, individuals with mild cognitive impairment and no dementia, and
individuals with dementia (Alzheimer's disease and non-AD forms including
frontotemporal dementia, primary progressive aphasia, and dementia with Lewy
bodies. The clinical data consist of demographic information, including health
and family history, and neuropsychological test scores. Subjects are tested
annually and some have been followed for up to 8 years. The tissue samples
include blood and extracted DNA, and some participants who have expired have
donated their brains for scientific study. The following table lists the
currently available clinical data and tissue samples for all registry
participants, and the characteristics of currently active subjects in our
Clinical Core registry.
NADC Data Available (last updated 7/26/07)
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Clinical Diagnosis
|
N
|
DNA
samples
available
|
Post-mortem tissue
available
|
Neuropathological
Diagnoses*
|
Currently
Active Subjects
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Age
Range
(avg)
|
Educ
Range
(avg)
|
CDR
Range
(avg)
|
MMSE
Range
(avg)
|
|
Probable Alzheimer’s disease (PRAD)
|
213
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137
|
44
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AD = 30
AD + DLB = 6
DLB = 3
Other = 3
Pending = 2
|
77
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48-94
(77.1)
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6-20
(14.1)
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0.5-3
(1.7)
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0-29
(16.8)
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Possible AD or Vascular Dementia, or Mixed
|
112
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101
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23
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AD = 8
AD + VAD = 5
VAD = 5
DLB = 2
Other = 3
|
14
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73-94
(82.1)
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7-20
(14.6)
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0–3
(1.8)
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3–29
(20.6)
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Frontotemporal dementia or Primary Progressive Aphasia
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197
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145
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45
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AD = 21
FTD = 12
Pick = 2
Other = 10
|
78
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54-84
(68.3)
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12-20
(16.0)
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0–3
(1.2)
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0-30
(18.2)
|
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Lewy Body Dementia
|
25
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17
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7
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DLB = 6
AD = 1
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9
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71-85
(77.0)
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13-20
(16.4)
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1–3
(1.9)
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3–28
(16.6)
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Motor Neuron Dementia or ALS
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71
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42
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16
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ALS = 5
FTD-MND = 3
AD = 2
CBGD = 2
Other = 4
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12
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58-79
(69.3)
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12-20
(15.8)
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0–3
(2.1)
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12–28
(22.8)
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Normal Control
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396
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305
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3
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Normal = 2
Early AD = 1
|
227
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56-97
(76.0)
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3-21
(15.9)
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0-0.5
(0.0)
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24-30
(29.2)
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Mild Cognitive Impairment
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234
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155
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4
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Early AD = 2
AD = 1
VAD = 1
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61
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61-88
(76.8)
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9-20
(15.7)
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0–0.5
(0.3)
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23-30
(28.0)
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Other/Pending
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43
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21
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6
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AD = 2
DLB = 1
CJD = 2
Other = 1
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6
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64-90
(73.7)
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12-20
(17.5)
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0–0.5
(0.3)
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18-30
(22.1)
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TOTAL
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1366
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923
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148
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484
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74.5
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14.9
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0.9
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23.2
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*AD = Alzheimer’s disease; DLB = Diffuse Lewy Body Disease;
FTD = Frontotemporal degeneration; VAD = Vascular dementia;
CBGD = Corticobasalganglionic degeneration; CJD =
Creutzfeldt-Jacob disease
Clinical Subject Request Form
Data Request Form
Tissue Request Form
NADC Data Sharing Policy
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